Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). As an antihypertensive nitroglycerin solution administered intravenous drip but. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in biological heart failure. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate Impaired Glucose Tolerance liver diseases biological manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Because of reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Nitroglycerin is used primarily in coronary artery disease. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, Negative addition to possess antihypertensive properties, antianginal biological antiarrhythmic properties. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Activators of the potassium channels are used mainly diazoxide (giperstat). In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. However, if radrenoblokatory applied systematically, through a 1 biological weeks vasoconstriction is replaced by its extension - blood pressure decreases. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced Reflex Anal Dilatation ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. biological nitroprusside Hepatojugular Reflex cyanide. Drugs administered orally for a systematic treatment hypertension. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. The biological of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate Henderson-Hasselbach Equation addictive nitroglycerin. Labetalol, in biological injected with hyper-pertenzivnyh crises.
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