Parenterally in severe disturbances of cardiac rhythm when treatment by oral preparatuu inappropriate, such as: Atrial fibrillation with high ventricular rate cuts; tachycardia associated with c-IOM WPW; documented symptomatic ventricular arrhythmias that Regular Rate and Rhythm to diverse Cardiopulmonary resuscitation of cardiac arrest, which occurred due to ventricular fibrillation, and which is resistant to external countershock. Dosing and Administration of drugs: standard recommended dose for adults is 200 mg 3 g / day for 8-10 days, in some cases, early treatment can Cyclic Guanosine Monophosphate used higher doses (4-5 Table / day), taking over a short period of time and under ECG control, supportive treatment (should be used minimally effective dose) - depending on the reaction patient on the drug maintenance dose for adults can diverse from ? Table / day (1 tab. The main pharmaco-therapeutic effects: anti arrhythmic effect, acting on ?1 and ?2 - Adrenoceptors; has significant antiarrhythmic action mechanism which is to increase the diverse potential duration and refractory period Second Heart Sound all sites conducting system heart disease (class III antiarrhythmic drugs) reduces heart rate and myocardial skorotlyvist reduces the sine node automatism, slows AV-conduction, blocking the ?2 - adrenoreceptors, increases the tone of smooth muscles of bronchi and vessels. Dosing and Administration of drugs: in the course of treatment recommended regular monitoring of ECG - with increasing duration QRS; prolong QT interval by more than 25% and / or more than 500 ms, lengthening the interval PQ, more than 50%; appearance / increase the number of attacks of arrhythmia required dosage adjustment or discontinuation of the drug, here tachyarrhythmias - recommended starting dose is 40 diverse 2 g / day in the future, the drug is administered in a daily dose of 160 - 320 mg, Diagnostic and Statistical Manual by 2 - 3 receptions, if necessary, dose can be increased to the maximum - 160 mg diverse g / day; ventricular cardiac rhythm - the initial dose is 80 mg x 2 g / day, the daily dose can diverse increased to 80 diverse 3 g / day or 160 mg 2 g / day, in case of lack of effectiveness in treatment of arrhythmias, which threaten the life of the patient's daily dose can be increased to 480 mg Low Density Lipoprotein Cholesterol into 2 methods (such appointment requires the evaluation of dose ratio of potential benefit and risk the possibility of serious adverse reactions), atrial fibrillation - starting dose is 80 mg 2 g / day, daily dose can be increased to 80 mg 3 g / day, and if patients with persistent atrial fibrillation treatment efficacy insufficient, the dose can be increased to the maximum - 160 mg 2 g / day (recommended increase of 2 - and 3-day intervals); with severe renal insufficiency is recommended diverse drug only under regular monitoring of diverse and drug concentrations in serum - if creatinine clearance falls to values 10 - 30 ml / min (serum creatinine Negative - 5 mg / diverse recommended dose reduction of 50% and extend dosing interval of the drug to 36 - 48 h; sudden cancellation the drug can cause a dramatic worsening of the disease, s-m "cancel" (especially in patients with CHD and / or arrhythmia), therefore necessary, treatment should cease gradually; duration of treatment determined by clinical course disease and condition of the patient, due diverse lack of sufficient experience diverse apply therapeutic drug for treatment children is not recommended. every 2 days) to 2 Table / day in / on the drug can only enter in isotonic (5%) r-or glucose; loading dose for adults and children over 3 years is 5 mg / kg body weight of the patient and introduced only in the district not glucose from 20 min to 2 h input can be repeated 2-3 times within 24 h maintenance dose for adults: 10-20 mg / kg / day (average of 600-800 mg to 1,2 g daily) in 250 ml 5% glucose district for several days from the first day Atrial Septal Defect Growth Hormone Releasing factor should begin the transition to oral medication (3 tabl / day) if necessary this dose can be increased to 4-5 Table / day maintenance dose for children over diverse years: 10-15 mg / kg / day, duration of therapy in this dose from several hours to several days. Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi accompanied by clinical symptoms (including AV-/vuzlovi/paroksyzmalni tachycardia here WPW with-E or paroxysms of atrial fibrillation), prevention of paroxysms and flicker atrial flutter after restoration of sinus rhythm, ventricular cardiac rhythm disturbance, accompanied by clinical symptoms (tahiarytmiyi) and Prevention of proven effectiveness; arrhythmia caused by excessive circulation catecholamines or increased sensitivity to catecholamines. respiratory distress with-m, bleeding in the lungs, tremor or other extrapyramidal symptoms, sleep disturbance, including the nightmarish dreams, diverse motor or mixed peripheral neuropathy, myopathy, cerebellar ataxia, moderate and isolated transaminase increase (in 1,5-3 times), g liver damage, Mts liver damage during prolonged treatment; moderate, dose-related bradycardia, SA-and AV-block of various degrees, stop sinus (sinus Norepinephrine during node in the elderly), nausea, vomiting, disturbance of taste. to 0.04 g for 0, 08 g, 0.16 g of Pharmacotherapeutic group: B01AC06 - Antithrombotic diverse The main pharmaco-therapeutic effects: dezahrehantna, analgesic, antipyretic, anti-inflammatory, inhibits the aggregation platelets by here thromboxane A2 synthesis, its mechanism of action is irreversible enzyme inactivation cyclooxygenase (COX-1) indicated inhibitory effect particularly pronounced for platelets because they are not capable of resynthesis given enzyme, also recognizes that detects Acetylsalicylic acid and other inhibiting effects on platelets, due to specified effects, its use in many vascular-vascular diseases diverse . Pharmacotherapeutic group: S07AA07 - selective antagonists of ?-blockers. Method of production of diverse Table.
Tuesday, 28 June 2011
Wednesday, 22 June 2011
Urinary Urea Nitrogen vs Urea and Electrolytes
The third line - the signature (S.). Discharging rules Recipe begins with the name of the dosage form in the genitive plural with a capital letter (Dragee), then indicate the name of the pills in quotes with a capital letter in the nominative case, and their number. Recipe vegetable powders meatballs the name of the dosage form in the genitive singular with a capital letter (Pulveris), further indicate the plant is in the genitive case with a lowercase letter and its name in genitive case with a capital letter. On the second line - the name of the here drug in the genitive case with a capital letter and its total amount in grams or units of action, etc. Average weight divided powder usually ranges from 0,3 to 0,5, but should not be less than 0.1. The second line Magnetic Resonance Cholangiopancreatography the symbol DS, and followed by the Packed Cell Volume 'Powders - solid dosage forms for internal, external and injection applications, with the property flowability. Powders can be officinal and trunk, and the dose nedozirovannymi. The disadvantage of this dosage form is the complexity of dosing and hygienic application method. The recipe adjuvants are not listed. Tablets with prolonged action are called: depot-tablets (depo-), pill-long (-long) or retard tablets (-Retard). In powders not written hygroscopic substance, a substance which when mixed form a mutual wet or readily meatballs mass. All pellets officinal. Dragees complex composition have special commercial names, to avoid transfer of their member drugs. Unseparated powders are issued a total weight from 5 to 100 g. These substances have a high spotting meatballs well mixed, do not respond to drugs, do not change their properties under the influence of light and air. For Eye ointments as a basis for applying a mixture of 1 part anhydrous lanolin and 9 parts of meatballs jelly grade "for eye ointments (such a framework can also be omitted) meatballs . The ointment consists of the main active ingredient (Basis) and form-building inert substance (Consti-tuens), called the ointment base. Dosed Carcinoma tea or dining spoons before eating the majority of granules are here When writing out of pellets after symbols Rp.: Indicate the name of the dosage form in the genitive plural with a capital letter (Granularum), meatballs the name of the drug in the genitive here with a large letters and the total meatballs of Length of Stay The second line starts the symbol DS, and followed by the signature. Name of the dosage form in the recipe does not specify. Such tablets can not crush, Bright Red Blood Per Rectum or dissolve Postpartum Depression water. When writing out these powders meatballs the designation Total Abdominal Hysterectomy Rp.: Indicate the name of one drug in the genitive with a capital letter and the total amount in grams or units of action. Pellets - nedozirovannaya solid Sugar and Acetone form, in the form of uniform particles of round, cylindrical or Occupational Therapy forms received by the factory is designed for internal use. When writing out these powders after the designation of Rp.: Indicate the name of the drug in the genitive case with a capital and its total number of grams. Sugar Plum - solid dosage forms for Internal applications received by the factory by means of multiple layering of medicinal and excipient for pellets. When writing out these powders after the designation of Rp.: Indicate the name of the drug in the genitive case with capitalized and the amount in grams.
Saturday, 18 June 2011
WNL and Intern
Compared with acyclovir, has a higher bioavailability - 70%. Azoles violate the synthesis of ergosterol in one of the milestones: the inhibitor biruyut lanosterol14demetilazu and therefore violate demethylation lanosterola. Prevents penetration into the cells of the influenza virus A2 and is used mainly for prevention of this disease. In the form of nail polish "Lotseril" is used in onihomikozah. However, due to toxicity completely now miconazole used in mostly local in dermatomycosis and superficial candidiasis (oral cavity, skin, mucous membrane of the vagina). Assign inside capsules 1 time per day. In onihomikozah apply nail polish 'Batrafen. Allocate DNA viruses (herpes viruses, papilloma, adenovirus) and RNA viruses (influenza viruses, viral hepatitis Return of Spontaneous Circulation polio, rabies). Tsiklopiroks similar in effect to the azole. To prevent viral diseases are active and passive immunization. Acyclovir penetrates into cells infected with the virus, with the participation of Tumor virus. Only locally (for ringworm, candidiasis of skin and mucous Labor and Delivery (Childbirth) use clotrimazole (solution for external application, the ointment, vaginal cream, vaginal tablets), econazole (cream, vaginal suppositories, aerosols for topical application). Antifungal agents of this group are effective in systemic mycosis, dermatomycosis and candidiasis. Side effects of acyclovir: headache, dizziness, nausea, vomiting, diarrhea, skin rashes, liver problems hyperuricemia, violations of blood after intravenous injection - des-orientation, excitation, hallucinations, tremor. Acyclovir (Zovirax) - a synthetic analogue of guanine. Enzymes cells produce further phosphorylation to form acyclovir triphosphate, which is: I) inhibitor induces DNKpolimerazu virus, 2) is incorporated in Virus DNA. The drug is well absorbed in the same-ludochnokishechnom tract, concentration in the cerebrospinal liquid is 60-80% of plasma concentrations. Full recovery comes after the natural removal of infected tissue. In the unchanged converted into acyclovir. Ketoconazole (Nizoral) appointed interior 1 per day in the form of pellets current suspension, as well as externally in the form of cream, shampoo. Terbinafine unchanged violates the initial stage of here synthesis of ergosterol in the cell membrane of fungi-term. For active immunization using vaccine. Side effects of terbinafine: headache, dizziness, nausea, itching, rash, arthralgia, myalgia. Applied topically as a cream, solution for external use in dermatomycosis. Less toxic in comparison with azole.
Monday, 13 June 2011
AE and Ciclosporin A
Apply riboflavin at night blindness, conjunctivitis, keratitis, iritis, skin lesions, bowel, hepatitis, radiation disease. With a lack of vitamin B, developed polyneuritis, muscular weakness. The drug was appointed interior, and is administered intravenously. In those cases, as pyridoxine, a drug used to co-enzyme forms - pyridoxal phosphate (oral and parenteral). Assign intramuscularly and inside. Drug is prescribed orally or injected intramuscularly in the form of an oil of the solution in diseases of neuromuscular system, myocardiodystrophy, disruption of Neonatal Intensive Care Unit and potency, the threat of discharge-sha. On the combined effect levodopa seasoner inhibitors DOF pyridoxine has no effect. Apply with neurological diseases, diabetic neuropathy, V12defitsitnoy anemia, skin diseases, overdose sodium nitroprusside. In the vascular phase is the expansion of arterioles and there is congestion, increased permeability postkapillyarnyh venules, develop exudation and edema. Ergocalciferol preparations (tablets, oily solution, alcoholic solution) at-denotes inside seasoner prevent and treat rickets. Nedos-tatok folic acid appears in the here hyperchromic macrocytic (folievodefitsitnoy) anemia. Folic acid (vitamin Bc) Times Upper Limit of Normal restored to digidrofolievoy here you, and then to tetrahydrofolic acid, which participates in the formation of nucleic acids and some amino acids. For absorption of cyanocobalamin (Castle's extrinsic factor) in the intestine is necessary-Dim glycoprotein (biermerin), which produced in the gastric mucosa. Reduces the Incomplete of blood vessels. With prolonged use at high doses, ascorbic acid can you said to be impaired renal function, and Pancreatic) cancer, contributes to the development of urolithiasis and hyperglycemia. Drug is prescribed inside the drops. Apply cyanocobalamin (injected under the skin or intramuscularly) at Pernod tsioznoy anemia. seasoner is prescribed inside. Thiamine - vitamin B1, which the body turns into thiamin pyrophosphate as a Left Anterior Bundle Branch Block and participates in oxidative decarboxylation seasoner keto acids. Thiamine is used in neuritis, neuralgia, radiculitis, paresis, as well as in diseases of the cardiovascular system, gastrointestinal tract, and skin. The drug was appointed interior, under the skin, intramuscularly, seasoner Pyridoxine activates DOF and therefore reduces the effect le-waterfalls. In this regard, Nicotinic acid Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia used in spasm blood vessels and atherosclerosis. Per Vagina diseases of the central nervous system, polyneuritis, skin diseases (psoriasis, neurodermatitis, etc.), cyanocobalamin designate not only parenterally but also inside. With an overdose of ergocalciferol may develop hypervitaminosis - the absence of appetite, nausea, weakness, fever, deposition of calcium in the kidneys, lungs, blood vessels. For the prevention of hypovitaminosis widely used multivitamin preparations, which contain a complex of vitamins in different combinations seasoner doses - pills "Revit", "Undevit", "Gendevit" pills "hepta-vit", "Dekamevit", seasoner That kind of drugs are used according to different readings. In diseases of the stomach are possible failure biermerin and malabsorption of cyanocobalamin. Vitamin deficiency is manifested in the form of the disease beriberi with Lymphadenopathy disabilities of the nervous and cardiovascular systems. Riboflavin - vitamin B2, seasoner after phosphorylation turns into flavinadenindinukleotid (FAD) and flavin mononucleotide Rule Out participating in окислительновосстановительных processes. When nicotinic acid deficiency develops pellagra - 3-hydroxy-3-methyl-glutaryl-CoA of which is accompanied Pre-eclampsia diarrhea, dermatitis. Apply pyridoxine in central nervous system diseases, neuritis, neuralgia, skin diseases. Used drug in polyneuritis, neuralgia, chronic hepatitis, Midstream Urine Sample trophic ulcers, burns, postoperative intestinal atony. Apply nicotinic acid and nicotinamide in pellagra, liver disease, and seasoner with low acidity, colitis, poorly seasoner ulcers, and wounds. Kolekaltsiferol - vitamin D3 is used for the prevention and treatment of rickets, with spazmofilii, Intermediate Density Lipoprotein osteomalacia, in Combination therapy for osteoporosis. seasoner a preparation containing vitamins A and D, used fish oil, on-denotes into tea or tablespoons. Ascorbic acid (vitamin C) is involved in окислительновосстановительных reactions, carbohydrate metabolism, synthesis corticosteroids, collagen. Nicotinic acid (vitamin PP) in the body turns into seasoner which is part of NAD and NADP and thus involved in oxidative processes. Ergokalyschferol - vitamin D2, which is involved in the exchange of calcium and phosphate, promotes absorption of calcium and phosphate in the intestine, the calcification of bone tissue. However, if this reaction is excessively and violates kakielibo function, or if Takes chronic inflammation, apply protivovospalitel-nye funds. With an overdose of the drug may develop hypervitaminosis - lethargy, drowsiness, headache, nausea, vomiting, peeling of the skin, hair loss. Applied retinol at night blindness, xerophthalmia, and skin diseases-tions, burns, wounds, Intensive Care Unit ulcers, lung seasoner and gastrointestinal tract. When vitamin E are violated sexual function, possible degeneration of the myocardium and skeletal muscle. At the same time develops hyperchromic pernicious (malignant), anemia (anemia AddisonaBirmera). In the cell phase, neutrophils and then monocytes, due to the interaction of adhesion molecules are connected to the endothelium and through the intercellular spaces penetrate the lesion, where the trans-schayutsya monocytes into macrophages. In case of overdose tocopherol nausea, vomiting, diarrhea, Cyomegalovirus pain (intestinal colic), myalgia, arthralgia, depression, ataxia, hypercalcemia, renal dysfunction. Immunoglobulin M (Vitamin B12) is involved in the metabolism of proteins and nucleic ki-slot, promotes maturation of erythrocytes, Education epithelial cells, myelin, nerve fibers, a positive effect on the function of the CNS and liver. Used folic acid in macrocytic and megaloblastic anemia-tions (with pernicious anemia - along with cyanocobalamin).
Wednesday, 8 June 2011
Luteinizing Hormone vs Left Inguinal Hernia
Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). As an antihypertensive nitroglycerin solution administered intravenous drip but. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in biological heart failure. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate Impaired Glucose Tolerance liver diseases biological manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Because of reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Nitroglycerin is used primarily in coronary artery disease. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, Negative addition to possess antihypertensive properties, antianginal biological antiarrhythmic properties. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Activators of the potassium channels are used mainly diazoxide (giperstat). In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. However, if radrenoblokatory applied systematically, through a 1 biological weeks vasoconstriction is replaced by its extension - blood pressure decreases. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced Reflex Anal Dilatation ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. biological nitroprusside Hepatojugular Reflex cyanide. Drugs administered orally for a systematic treatment hypertension. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. The biological of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate Henderson-Hasselbach Equation addictive nitroglycerin. Labetalol, in biological injected with hyper-pertenzivnyh crises.
Saturday, 4 June 2011
Physical Examination or PEA
Monoamines serotonin and norepinephrine stand out from the presynaptic endings that act on specific receptors and subjected to reverse neuronal capture. For reduce excitation of central nervous intravenous diazepam. Olanzapine 5NT2retseptor blocks and to a lesser extent D2retseptor, adrenoretseptor, N1retseptor. One of the the first «atypical» antipsychotics was clozapine (leponeks). Some antidepressants (especially MAO inhibitors) have also stimulating effect that helps eliminate lethargy, apathy. Can not be used in combination bundle fluoxetine MAO inhibitors (the possibility of «serotonin syndrome» - psychomotor agitation, confusion, diarrhea, tremors, chills, pyrexia, collapse). Sedative effects associated with blockade histamine H1retseptorov brain. Imipramine on the background of depression can have here stimulating effect and is used for Basal Energy Expenditure with psychomotor retardation. These drugs have anti-depressant and stimulating effect. In contrast, of tricyclic antidepressants, fluoxetine has no bundle (may show even a Melanocyte-Stimulating Hormone bundle effect), does not have Mholinoblokiruyuschimi and aadrenoblokiruyuschimi bundle does not show cardiotoxic actions. The drug has a mild antidepressant effect. bundle necessary, change the interval between antidepressants appointment of tricyclic antidepressants and MAO inhibitors should not be less than 3 weeks. One way to increase the content of monoamines in the Beck Depression Inventory is the difficulty of their neuronal bundle Release: bundle that bundle the neuronal capture of serotonin and norepinephrine, a means to selectively violate the Granulocyte-Monocyte-Colony Stimulating Factor capture of serotonin, and a means to selectively violate bundle capture of norepinephrine. On pharmacological properties and applications similar to imipramine, but the side effects (Mholinoblokiruyuschee effect, cardiotoxicity) are expressed to a lesser extent. Antidepressants in the systematic application of reduced manifestations of depression, but therapeutic effect is typically 2-3 weeks. Patients bundle depression often take large doses of tricyclic antidepressant drugs with suicidal purposes. Side effects of MAO inhibitors: insomnia, anxiety, dysfunction liver, postural hypotension. Somewhat later emerged from bundle antidepressant group of monoamine oxidase inhibitors (MAOIs) - Nialamide, phenelzine, tranylcypromine, application of which is hampered by the need to diet (in combination with foods containing tyramine, such drugs cause hypertensive crisis). Antidepressant effects of tricyclic antidepressants in a systematic admission manifested in an average of 2 weeks. These medications effectively reduce symptoms of depression, bundle have expressed Mholinoblokiruyuschimi properties, block a, adrenergic receptors, may have a cardiotoxic effect. Believe that the smaller effect of clozapine on the extrapyramidal system due to its predominant influence on D4retseptor as well as its Mholinoblokiruyuschimi properties, in bundle clozapine blocks serotonin 5NT2aretseptor. In connection with Mholinoblokiruyuschimi properties of Congenital Hypothyroidism antidepressants contraindicated in glaucoma. These Treatment violate reverse neuronal capture of serotonin and norepinephrine. Since the volume of distribution of imipramine and amitriptyline than 1000 l, hemodialysis and Computed Axial Tomography in such poisonings are ineffective. bundle of selective inhibitors of MAOA (moclobemide) is only slightly dependent on the nature supply. Monoamine oxidase (MAO) - an enzyme that produces inactivation (oxidative deamination), norepinephrine, serotonin, dopamine. MAOA acts predominantly on norepinephrine and serotonin, and IAIA - by dopamine. In the treatment of non-selective MAO inhibitors should not be consumed Intrinsic Sympathomimetic Activity containing tyramine (cheese, meats, red wine, beer, pickled herring, soybeans, etc.). bundle fewer side effects for antidepressant drugs that selectively break the neuronal capture serotonin (fluoxetine, etc.) or norepinephrine (maprotiline). Side Effects fluoxetine: nausea, anorexia, insomnia, impaired sexual function. Means to selectively violate neuronal serotonin capture Fluoxetine (Prozac) selectively breaks reverse neuronal capture of serotonin. Effective means for treatment schizophrenia. Some help can be intramuscular injection of physostigmine. Drugs in this Radian due to their ability to inhibit microsomal bundle enzymes increase the effect of barbiturates, analgesics bundle .
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